Image of the Quarter

Strongly amplified HER2 FISH - 'Mouse-over' for arrows:

strongly amplified HER2 FISH

The green arrow points to a clump of HER2 signals (pink/red in colour).
The blue arrow points to one of two CEP17 signals (faint blue dots) in the cell.
Most of the cells in this image are diploid & many cells show two clumps of HER2 signals.



I am delighted to provide a link for the LORIS Trial which opened at the beginning of last year. The Trial compares surgery with surveillance for low risk DCIS. We have a poster at the San Antonio Breast Cancer Symposium and I would be delighted to say hello to colleagues if you are at the symposium and are in the Poster Hall on evening of Dec 8th.

The latest Image of the Quarter is a really lovely example of amplified HER2 FISH.

Colleagues have approached me to see if there was an appetite to publish brief case reports on this site. If there is enthusiasm I will set up a special section. If there is interest please contact me at this address:

The site is now over ten years old - it went live in February/March 2006. I am grateful to all the vistors, colleagues and trainees who help to encourage its further growth and development. Visitor numbers are steady at about 18,000 a month. The most frequently accessed pages remain broadly unchanged from previous years.

I am absolutely delighted to continue to work with colleagues on the Sloane Project. We have previously updated the ADH page on that site and I have used those images and text to update this site's Sloane Project ADH page in line with that. The Sloane Project is going from strength to strength. The steering group is immensely fortunate to have been guided by the expert chairmanship of Hugh Bishop succeeded two years ago by Professor Alastair Thompson with fantastic support from the NHS Breast Screening Programme. We are well advanced in consolidating our data and are about to publish some very interesting results on recurrences.

Background, aims & optimum viewing:


An easily accessible entry point to the understanding of the pathology of breast diseases
Uses the flexibility of the web to allow rapid updating


Trainees in breast pathology
Teachers seeking educational material
The wider public


Cross-specialty topics such as immunohistochemistry and specimen handling protocols
Very richly illustrated with 'mouse-over' features on many illustrations
Extensive hyperlinking throughout site - easily navigable


Internet Explorer 5.0, Firefox 1.5 or Opera 9.0 or above
Screen resolution of 1280x800
Broadband internet connection


An evolving resource to cover all main areas of breast pathology
Developing links with other educational sites
Providing topical information
Developing interactive functionality


Dr Jeremy Thomas, Lead Consultant Pathologist, Edinburgh Breast Unit

Summary of topics covered on this site:


Specimen handling; BMS Trimming;
Reporting protocols; Communication;
Links to screening documents;


Immunohistochemistry; Genetics

Benign &

Epithelial proliferations - typical and atypical;
Fibroadenomas and related lesions;
Sclerosing lesions; Inflammations; Fibromatosis


Carcinoma in situ;
Common and uncommon cancers;
Grading and staging breast cancer;
Prognosis of breast cancer

It is emphasised that these pages are complementary to the many excellent texts and aids available to the student of breast pathology. The author recommends the following references as a starting point:

Site last updated 26/01/2018

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