Lobular Neoplasia


This is an area of great interest and a very valuable part of the Sloane Project. The clinical significance and natural history of lobular neoplasia is far from being fully understood and most published series have relatively small numbers of cases. It is anticipated that the Sloane Project will accrue between 100 and 150 cases in this group and the follow up information will be extremely helpful in guiding future clinical management.



For the purposes of breaking this page up into accessible sections I have added links as follows:



The following sequence of images begins with some views of a normal terminal duct lobular unit (TDLU) to help put the lobular neoplasia images in context. High power views are comparable and have been taken with the same microscope and adjusted for the web identically.


Normal TDLU
Normal tdlu


Normal TDLU
Normal tdlu x20 Normal tdlu x40


Lobular neoplasia - ALH
Lobular neoplasia - ALH Lobular neoplasia - ALH


Lobular neoplasia - ALH - arrows point to luminal calcs
ALH with luminal microcalc


Lobular neoplasia - ALH - Further area from the same case. Note luminal calc.
ALH with luminal microcalc


Lobular neoplasia - ALH - Further focus from the same case. 'Mouse over' for a comparison with a normal TDLU
Lobular neoplasia - ALH and normal tdlu on 'mouse over'

Lobular neoplasia - ALH - Example 2. 'Mouse over' for high power view
Lobular neoplasia - ALH with high power view on 'mouse over'


Lobular neoplasia - ALH - Example 3
ALH - example 3


Lobular neoplasia - ALH - Example 3 - detail from image above. Partial replacement of normal acinar luminal epithelial cells (red arrows) by a neoplastic lobular epithelial population (blue arrows)
ALH with luminal microcalc


Lobular neoplasia - LCIS (example 1)
Lobular neoplasia - LCIS Lobular neoplasia - LCIS


Lobular neoplasia - LCIS (example 2)
Lobular neoplasia - LCIS Lobular neoplasia - LCIS

Lobular neoplasia - Florid or pleomorphic LCIS - Note negative E cadherin (lower right image)
Lobular neoplasia - Florid LCIS Lobular neoplasia - Florid LCIS
Lobular neoplasia - Florid LCIS Lobular neoplasia - Florid LCIS - E cadherin immunostaining


Lobular neoplasia - Florid LCIS
Lobular neoplasia - Florid LCIS


Lobular neoplasia - Florid or pleomorphic LCIS - Example 2
Lobular neoplasia - Florid LCIS Lobular neoplasia - Florid LCIS
Lobular neoplasia - Florid LCIS Lobular neoplasia - Florid LCIS


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