Immuno expression profiles for BRCA1 and BRCA2 assosciated breast cancers
Differential expression profiles of BRCA1 (Lower left) vs BRCA2 (Upper right) tumors.
The basal phenotype characterized by CK 5/6- and cyclin E-positivity and estrogen receptor, HER2-, and p27-negativity
is observed in BRCA1 tumors. Red indicates positive expression, green indicates negative expression.
Honrado E, Benítez J, Palacios J. The molecular pathology of hereditary
breast cancer: genetic testing and therapeutic implications. Modern Pathology 2005; 18:1305–1320. doi:10.1038/modpathol.3800453
With permission from The Nature Publishing Group.