HOME PAGE PRACTICE & PROTOCOLS INVESTIGATIONS BENIGN / BORDERLINE MALIGNANT CASE MATERIAL

Image of the Month (2011-3)



Pregnancy-like change with lamellated secretions



50 year old female - Calcs on mammogram

Pregnancy-like change with lamellated secretions - low power

Detail - from above. Note acinar spaces containing multiple psammoma-like microcalcs. 'Mouse over' for further detail.

Pregnancy-like change with lamellated secretions - low power


High power view of concretion. Note lamellation and calcification. Arrow points to foamy cytoplasmic change in acinar epithelium (pregnancy-like) ('Mouse over')

Metaplastic carcinoma with heterologous focus

Associations:

  • Generally considered an incidental finding


  • May follow pregnancy by 3-25 years

    • Occasionally no history of pregnancy
    • Patient may be of any age

  • May be associated with drug therapy:

    • Hormones
      • Reported in males receiving oestrogen for prostate carcinoma
    • Antipsychotic drugs
    • Antihypertensive drugs

  • Benign, no association with carcinoma


See also Stanford School of Medicine Sugical Pathology Criteria.


See also Benign microcalcification - lactational change

I am grateful to my colleague, Dr David Worrall, who kindly contributed this interesting case



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