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Image of the Quarter (2012-2)



Collagenous spherulosis



50 year old female - excision biopsy left breast for papillary lesion - widespread benign proliferative changes surrounding an intraduct papilloma (not illustrated here). There were scattered small foci showing changes illustrated below.


Duct space showing predominantly columnar cell change without atypia. Small focus of collagenous spherulosis on right hand side.

Collagenous spherulosis
Collagenous spherulosis - low power


Detail of glandular spaces. ('Mouse over' Arrows A & B show the two cell types that surround the spaces - luminal and myoepithelial. Arrow C shows the lamellated collagenous material lining the spaces - in some cases the entire space is filled with this material.)

Collagenous spherulosis


  • This is an uncommon finding usually seen incidentally associated with benign proliferative disease of the breast


  • The important point here is not to mistake the lesion for cribriform pattern DCIS. If there are doubts on this point then the two cell types (luminal and myoepithelial) can be distinguished immunohistochemically eg using CK5/6 or CK14




See also cribriform DCIS .


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