HOME PAGE PRACTICE & PROTOCOLS INVESTIGATIONS BENIGN / BORDERLINE MALIGNANT CASE MATERIAL

Image of the Quarter (2015-2)



A difficult core biopsy



55 year old woman - calcs on screening mammogram - core biopsy.




The biopsy shows DCIS on the left and top right of the image and apparent invasion in the central area. Mouse-over for detail.

DCIS with distorting sclerosis



These further H&Es show further detail of the central area of this biopsy.

DCIS with distorting sclerosis


These views are of CK 14 immunostaining where the apparent invasive disease is in fact bounded by an intect myoepithelial layer and is therefore in situ ('Mouse-over').

DCIS with distorting sclerosis - ck14 staining




This is a good example of DCIS with distorting sclerosis. A recent publication (Walters LL et al Histopathology 2015; 66: 565-576) indicates that when seen in a core biopsy it is associated with a high chance of invasion in the subsequent excision


See also Carcinoma in situ.


See also... Uses of immunohistochemistry in the assesment of invasion.

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